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The NICE clinical guideline on depression covers:

  • the care people with depression can expect to receive from their GP or other healthcare professionals, whether they receive treatment in or out of hospital

  • the information they can expect to receive about their problem and its treatment

  • what they can expect from treatment, including psychological therapies, drug treatment and electroconvulsive therapy

  • the kind of services that help people with depression, including your GP, specialist mental health services and hospital care

The guideline looks at depression in people aged 18 years and older, and covers mild to severe depression. It does not specifically look at:

  • depression in children

  • dysthymia

  • postnatal depression

  • seasonal affective disorder

  • people with depression who have a separate physical or mental illness

NICE reaction to MHRA announcement on revised prescribing advice for venlafaxine.

Please note that this guideline is currently being updated in two parts: the treatment of depression in people with chronic physical health problems (further information) and the treatment and management of depression in primary and secondary care (further information).


Guideline Product


Quick reference guide


Information for the public


Full guideline

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Appendix 1 - 16

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Appendix 17

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Appendix 18

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Appendix 19a

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Appendix 19b

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Appendix 19c

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Appendix 20

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Appendix7 addendum

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NICE guideline






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Info Icon | Copyright - Photographer: Andrzej Windak | Agency: Dreamstime.comRelated Information

NICE Technology Appraisals:

Depression and anxiety - computerised cognitive behavioural therapy (CCBT) (No. 97)

Electroconvulsive therapy (ECT) (No. 59)


Info icon | Copyright - Photographer: Andrzej Windak | Agency: Dreamstime.comDownloading files

All documents use PDF or HTML format. Click the file name to open the file in your web browser or right-click to save the file to your PC. Where you see the word NICE, clicking the file name will open a new window allowing you to download the file from the NICE website.

Info Icon | Copyright - Photographer: Andrzej Windak | Agency: Dreamstime.comPrinted versions

A printed version of the full guideline can be purchased from the RCPsych. Printed versions of some of the NICE products can be ordered here.